Scientists are getting a better handle on the complexities of how immunity works. Attentive readers might have noticed my absence over the last couple of weeks. I've been trying to recover from a bout of illness. It got me thinking about the immune system, and how little I know about my own immune health. The vast array of cells, proteins, and biomolecules that works to defend us from disease is mind-bogglingly complicated. Immunologists are still getting to grips with how it all works.

Recent discoveries have suggested that the promising avenue of using circulating tumor DNA (ctDNA) levels in blood samples provides reasonable accuracy for cancer monitoring, with extremely low burden on the patient's side. It is known that the presence of ctDNA can result from various mechanisms leading to DNA release from cells, such as apoptosis, necrosis or active secretion. One key idea in recent cancer monitoring studies is that monitoring the dynamics of ctDNA levels might be sufficient for early multi-cancer detection. This interesting idea has been turned into commercial products, e.g. in the company named GRAIL. In the present work, we propose to explore the use of Signature theory for detecting aggressive cancer tumors based on the analysis of blood samples. Our approach combines tools from continuous time Markov modelling for the dynamics of ctDNA levels in the blood, with Signature theory for building efficient testing procedures. Signature theory is a topic of growing interest in the Machine Learning community (see Chevyrev2016 and Fermanian2021), which is now recognised as a powerful feature extraction tool for irregularly sampled signals. The method proposed in the present paper is shown to correctly address the challenging problem of overcoming the inherent data scarsity due to the extremely small number of blood samples per patient. The relevance of our approach is illustrated with extensive numerical experiments that confirm the efficiency of the proposed pipeline.

Drones could be used for NHS-related missions in remote areas, inspecting offshore wind turbines and supplying oil rigs by 2026 as part of a new regulatory regime in the UK. David Willetts, the head of a new government unit helping to deploy new technologies in Britain, said there were obvious situations where drones could be used if the changes go ahead next year. Ministers announced plans this month to allow drones to fly long distances without their operators seeing them. Drones cannot be flown "beyond visual line of sight" under current regulations, making their use for lengthy journeys impossible. In an interview with the Guardian, Lord Willetts, chair of the Regulatory Innovation Office (RIO), said the changes could come as soon as 2026, but that they would apply in "atypical" aviation environments at first, which would mean remote areas and over open water. Referring to the NHS, Willetts said there was potentially a huge market for drone operators.

Background: Circadian desynchrony characterized by the misalignment between an individual's internal biological rhythms and external environmental cues, significantly affects various physiological processes and health outcomes. Quantifying circadian desynchrony often requires prolonged and frequent monitoring, and currently, an easy tool for this purpose is missing. Additionally, its association with the incidence of delirium has not been clearly explored. Methods: A prospective observational study was carried out in intensive care units (ICU) of a tertiary hospital. Circadian transcriptomics of blood monocytes from 86 individuals were collected on two consecutive days, although a second sample could not be obtained from all participants. Using two public datasets comprised of healthy volunteers, we replicated a model for determining internal circadian time. We developed an approach to quantify circadian desynchrony by comparing internal circadian time and external blood collection time. We applied the model and quantified circadian desynchrony index among ICU patients, and investigated its association with the incidence of delirium. Results: The replicated model for determining internal circadian time achieved comparable high accuracy. The quantified circadian desynchrony index was significantly higher among critically ill ICU patients compared to healthy subjects, with values of 10.03 hours vs 2.50-2.95 hours (p < 0.001). Most ICU patients had a circadian desynchrony index greater than 9 hours. Additionally, the index was lower in patients whose blood samples were drawn after 3pm, with values of 5.00 hours compared to 10.01-10.90 hours in other groups (p < 0.001)...

Although the terms are often confused or used interchangeably, sperm and semen are not the same thing. Semen is the fluid that comes out of the penis, while sperm are the microscopic cells within the semen. Sperm cells are specialized for the task of fertilizing an egg. Semen analysis is considered essential for diagnosis of male infertility, but is not readily available at medical institutions other than those specializing in infertility treatment. 'Fertility specialists take it for granted that the first step in diagnosing male infertility is to perform a semen analysis,' Professor Kobayashi added.

When systems use data-based models that are based on machine learning (ML), errors in their results cannot be ruled out. This is particularly critical if it remains unclear to the user how these models arrived at their decisions and if errors can have safety-relevant consequences, as is often the case in the medical field. In such cases, the use of dependable methods to quantify the uncertainty remaining in a result allows the user to make an informed decision about further usage and draw possible conclusions based on a given result. This paper demonstrates the applicability and practical utility of the Uncertainty Wrapper using flow cytometry as an application from the medical field that can benefit from the use of ML models in conjunction with dependable and transparent uncertainty quantification.

Diagnosing rare anemia disorders using microscopic images is challenging for skilled specialists and machine-learning methods alike. Due to thousands of disease-relevant cells in a single blood sample, this constitutes a complex multiple-instance learning (MIL) problem. While the spatial neighborhood of red blood cells is not meaningful per se, the topology, i.e., the geometry of blood samples as a whole, contains informative features to remedy typical MIL issues, such as vanishing gradients and overfitting when training on limited data. We thus develop a topology-based approach that extracts multi-scale topological features from bags of single red blood cell images. The topological features are used to regularize the model, enforcing the preservation of characteristic topological properties of the data. Applied to a dataset of 71 patients suffering from rare anemia disorders with 521 microscopic images of red blood cells, our experiments show that topological regularization is an effective method that leads to more than 3% performance improvements for the automated classification of rare anemia disorders based on single-cell images. This is the first approach that uses topological properties for regularizing the MIL process.

The shape of erythrocytes or red blood cells is altered in several pathological conditions. Therefore, identifying and quantifying different erythrocyte shapes can help diagnose various diseases and assist in designing a treatment strategy. Machine Learning (ML) can be efficiently used to identify and quantify distorted erythrocyte morphologies. In this paper, we proposed a customized deep convolutional neural network (CNN) model to classify and quantify the distorted and normal morphology of erythrocytes from the images taken from the blood samples of patients suffering from Sickle cell disease ( SCD). We chose SCD as a model disease condition due to the presence of diverse erythrocyte morphologies in the blood samples of SCD patients. For the analysis, we used 428 raw microscopic images of SCD blood samples and generated the dataset consisting of 10, 377 single-cell images. We focused on three well-defined erythrocyte shapes, including discocytes, oval, and sickle. We used 18 layered deep CNN architecture to identify and quantify these shapes with 81% accuracy, outperforming other models. We also used SHAP and LIME for further interpretability. The proposed model can be helpful for the quick and accurate analysis of SCD blood samples by the clinicians and help them make the right decision for better management of SCD.

From a pig heart being successfully transplanted into a human, to being able to redirect an asteroid on a collision course with Earth, there have been all manner of weird and wonderful scientific discoveries in 2022. They include the human genome finally been mapped after two decades, the unearthing of Africa's oldest known dinosaur, and the release of the first ever image of a supermassive black hole at the heart of our Milky Way galaxy. There was also the alarming discovery that microplastics are everywhere – including in us – and the hugely-anticipated first images from the world's most powerful space telescope James Webb, which will peer back to the dawn of the universe. Here, MailOnline looks at 10 of the most interesting advances this year. The year began with a bang scientifically when just a week into it a dying man became the first patient in the world to get a heart transplant from a genetically-modified pig.

Rose Nakasi and her colleagues have developed a machine-learning method to detect malaria parasites in blood samples. We spoke to Rose about the motivation for this project, the progress so far, and what they are planning next. The problem that we are trying to solve concerns the microscopy of malaria diagnosis. The motivation for this research is that malaria is one of the most highly endemic diseases in sub-Saharan Africa, Uganda included. The major problem is that the gold-standard confirmatory test for diagnosis is by use of a microscope, and in our setting, we have a shortage of skilled lab microscopists that are able to carry out the correct diagnosis of the disease.